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Gene Expression Literature Summary
Assay
Age
In situ RNA (whole mount)
11.5 DPC

12 matching records from 12 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Six2  sine oculis-related homeobox 2  
Results  Reference
1J:100575 Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP, Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92
1*J:137184 Fogelgren B, Kuroyama MC, McBratney-Owen B, Spence AA, Malahn LE, Anawati MK, Cabatbat C, Alarcon VB, Marikawa Y, Lozanoff S, Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice. Dev Dyn. 2008 Jul;237(7):1767-79
1J:172359 Goncalves A, Zeller R, Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos. PLoS One. 2011;6(4):e19370
1J:171512 Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ, Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development. 2011 Apr;138(7):1247-57
1J:95309 Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N, Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development. 2005 Feb;132(3):469-78
1*J:23775 Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P, Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
1J:219797 Ranghini EJ, Dressler GR, Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
1J:102845 Santagati F, Minoux M, Ren SY, Rijli FM, Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development. 2005 Nov;132(22):4927-36
1*J:261953 Wang C, Wang J, Borer JG, Li X, Embryonic origin and remodeling of the urinary and digestive outlets. PLoS One. 2013;8(2):e55587
1J:334527 Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo MM, Trowe MO, Kispert A, Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Development. 2023 Mar 15;150(6):dev201048
1J:154470 Yallowitz AR, Gong KQ, Swinehart IT, Nelson LT, Wellik DM, Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol. 2009 Nov 1;335(1):156-65
1*J:196597 Yamamoto-Shiraishi Y, Kuroiwa A, Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. Dev Biol. 2013 May 15;377(2):363-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory